WEBVTT

1
00:00:00.643 --> 00:00:03.700
Five-year-old Ella Kroese needs a new heart.

2
00:00:08.317 --> 00:00:10.550
She was born with a serious heart defect.

3
00:00:10.712 --> 00:00:13.419
Three open-heart surgeries weren't enough to fix it.

4
00:00:15.919 --> 00:00:19.539
Only the right-sized heart with the right blood type will do.

5
00:00:20.099 --> 00:00:25.328
And even though she's in the top-priority category for a transplant, she's been waiting for months.

6
00:00:25.802 --> 00:00:31.893
Thousands of Americans like Ella are on the national waiting list for a new heart, according to the U.S. government.

7
00:00:32.792 --> 00:00:35.724
And even if they get one, their bodies may reject it.

8
00:00:38.890 --> 00:00:45.986
But, what if doctors could manufacture a heart with a patient's own cells using a 3-D printer,

9
00:00:47.804 --> 00:00:51.475
that new machine that makes everything from food to shoes to cars? 

10
00:00:52.202 --> 00:00:56.492
If that sounds like a pipe dream, say hello to the BioAssemblyBot.

11
00:00:57.962 --> 00:01:01.633
It's a robot that can already print several parts of the heart.

12
00:01:01.667 --> 00:01:04.055
I can tell the robot printer: build this for us.

13
00:01:04.545 --> 00:01:05.924
This is what we're going to print for you.

14
00:01:06.154 --> 00:01:15.987
Blood vessels, heart valves and the heart's walls -- it can print these parts with living human cells,

15
00:01:17.001 --> 00:01:22.967
and one of its masterminds believes it can print an entire heart within a moon-shot time frame.

16
00:01:24.415 --> 00:01:30.430
And I really think that if we put a large team together, which we are, I think we can get there within 10 years.

17
00:01:31.874 --> 00:01:37.255
Dr. Stuart Williams at the University of Louisville leads the team that's working toward this goal.

18
00:01:37.648 --> 00:01:39.903
And for Williams, the goal is personal.

19
00:01:40.467 --> 00:01:51.744
My dad died of heart disease, and the devices, the instruments that would really have been necessary to keep his heart functioning were not available at that time.

20
00:01:51.819 --> 00:01:58.549
So, it really grew out of a personal vendetta that I had against cardiovascular pathology.

21
00:01:58.784 --> 00:02:02.714
Now, he and his colleagues are pioneers in the field of bio-printing, ...

22
00:02:03.157 --> 00:02:05.126
We're taking biology and making it IT.

23
00:02:07.123 --> 00:02:14.375
...having built a six-axis robot that they say would create a heart right in the operating room.

24
00:02:14.797 --> 00:02:17.677
What would this look like visually? I'm still trying to understand.

25
00:02:17.890 --> 00:02:24.752
You'd press a button, and this thing would actually print a heart? Is that what would happen?

26
00:02:24.930 --> 00:02:26.330
Precisely. That is the plan.

27
00:02:26.690 --> 00:02:31.893
MRI images of a healthy heart would be converted into a digital 3-D model.

28
00:02:32.551 --> 00:02:38.727
Then the patient's own fat would be taken out and converted into the different cells that make up the heart.

29
00:02:38.986 --> 00:02:47.562
We now have these incredible capabilities to take an adult cell and transform it into other types of cells.

30
00:02:48.437 --> 00:02:55.324
Parts of the heart would then be bio-printed piece by piece, and soon you would have a new heart.

31
00:02:56.180 --> 00:02:58.723
How long would it take to print a heart?

32
00:02:58.824 --> 00:03:04.299
The printing of the heart, I believe, could be accomplished in essentially a single day.

33
00:03:05.877 --> 00:03:10.098
Dr. Williams and his team aren't the only bio-printers on the block.

34
00:03:11.633 --> 00:03:17.517
A group at Cornell University has bio-printed a human ear.

35
00:03:19.003 --> 00:03:22.777
Cold collagen gel being deposited onto the warm plate.

36
00:03:22.874 --> 00:03:26.176
What that enables you to get is really sharp edges and really sharp boundaries.

37
00:03:28.169 --> 00:03:33.288
It takes Dr. Larry Bonassar and his team just 15 minutes to print one.

38
00:03:33.464 --> 00:03:34.650
They're pretty robust.

39
00:03:34.941 --> 00:03:40.432
You know, I can pick them up, and they can bend and they can do all the things that normal cartilage should do.

40
00:03:42.147 --> 00:03:45.509
3-D printed ears and other body parts, Bonassar estimates, ...

41
00:03:45.673 --> 00:03:47.758
This is a meniscus.

42
00:03:48.018 --> 00:03:52.046
...could be used in human trials in less than five years.

43
00:03:52.447 --> 00:03:58.408
It brings the ability to make thousands, millions of tissues and to customize them for individual people.

44
00:03:58.810 --> 00:04:03.051
And the heart has one major blood vessel called the left main artery.

45
00:04:03.081 --> 00:04:06.884
And what's stopping us from making better organs, asked Dr. Williams.

46
00:04:08.171 --> 00:04:15.059
Whoever put this original plan together, put one major blood vessel leading into the left side, the major part of the heart.

47
00:04:15.120 --> 00:04:19.083
And when that vessel becomes dysfunctional, we call it "the widow maker."

48
00:04:19.684 --> 00:04:22.689
When that vessel fails, a patient will often die.

49
00:04:23.162 --> 00:04:31.485
So, we can build a new heart based upon a design that has two or three blood vessels, a redundancy in this organ.

50
00:04:32.221 --> 00:04:39.030
Do you sometimes worry that you are playing god, that you're actually creating human beings, parts of human beings?

51
00:04:39.109 --> 00:04:46.779
Well, I don't worry about that, but I certainly hope that this technology can benefit as many people as possible.
